Degeneration regeneration of peripheral nerves musculoskeletal system structure of peripheral nerves nerve conduction musculoskeletal system contraction of skeletal muscle musculoskeletal system walking movements of the foot nervous system higher functions of the nervous system. Regeneration and degeneration types of inflammation change with aging for about 100 years it has been popular to explain the degenerative diseases as the result of mutations in the genes a slow accumulation of somatic mutations as opposed to the germ cell mutations that are involved in huntingtons chorea and sickle cell anemia. The center for regenerative medicine is developing new tools to effectively control the process of neural injury and degeneration and to create a microenvironment that enhances the capacity for innate repair and the efficacy of other regeneration strategies including neural cell replacement and neurorehabilitation. Wallerian degeneration refers to the well orchestrated morphologic and biochemical changes that occur in axons schwann cells and macrophages distal to a site of nerve injury resulting in the establishment of a microenvironment supportive of axonal regeneration
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